人抗β2糖蛋白IgM檢測Human Anti β2 Glycoprotein 1IgM ELISA kit 說明書

人抗β2糖蛋白IgM檢測試劑盒

Human Anti Beta2 Glycoprotein 1 (B2GP1) IgM ELISA kit 

 Cat#3300-195-B2M

Intended Use

ADI’s Anti-Beta2-Glycoprotein IgM ELISA KIT an indirect solid phase enzymeimmunoassay (ELISA) for the determination of IgM class autoantibodies againstβ2GP1 in human serum or plasma or citrate/EDTA anticoagulated plasma. ELISAKIT is intended for research use only, not for use in diagnostic procedures.

General Information

β2-glycoprotein 1 (β2GP1) is a plasma glycoprotein and has been shown to be thedominant antigen for anti-phospholipid antibodies (APAs) in patients with anti- phospholipid syndrome. The presence of APAs such as anti-cardiolipin antibodiesis associated with venous and arterial thrombosis, recurrent spontaneousabortions and thrombocytopaenia. Anti-cardiolipin antibodies are also present inresponse to a variety of infections and certain drug treatments. A number of studieshave demonstrated that detection of β2GP1 antibodies, in conjunction with anti- cardiolipin measurement, is important in defining the thrombotic risk associatedwith APAs. β2GP1 IgG-antibodies are more closely associated with thrombosis inpatients with a history of anti-phospholipid antibody-associated diseases than anti- cardiolipin antibodies.

Detection Limit

The lower limit of detection, calculated as the mean of the zero standard plus two standarddeviations, run in duplicate in 20 assays was 0.1 U/mL.Interferences:Haemolysate up to 400mg/dl, bilirubin up to 0.2mg/mL and intralipid up to 15mg/mL do notinterfere with results.

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